Neuropeptide - anxiolytic
Selank
Synthetic tuftsin analog studied as an anxiolytic
Selank is a synthetic analogue of tuftsin, a naturally occurring immunomodulatory peptide. It was developed in Russia, where it has been used clinically as an anxiolytic, which makes it unusual among research peptides: it has an actual clinical history rather than only a preclinical literature.
That history is also its limitation. Most of the clinical work was published in Russian, outside the regulatory frameworks and trial registries that Western regulators rely on, so the evidence base is harder to assess than the volume of publications suggests.
Mechanism
GABAergic modulation
The proposed anxiolytic effect is generally attributed to influence on GABA signalling, the same system benzodiazepines act on, though through a different and less characterised route.
Enkephalin degradation
Selank has been reported to inhibit the breakdown of enkephalins, endogenous opioid peptides, which is a proposed contributor to its effects on anxiety and mood.
BDNF and monoamines
Animal work reports changes in BDNF expression and monoamine turnover, consistent with the broader neurotrophic framing the compound is marketed under.
Research status
There is a substantial body of Russian-language clinical and animal research, including trials for anxiety and asthenia, and the compound has been used clinically there. The limitations are significant for anyone outside that context: much of the work is not indexed in English-language databases, sample sizes are often small, and it has not been reviewed or approved by the FDA or EMA. Western peer-reviewed work is mostly animal and mechanistic.
Verifying a batch
- 01Confirm the sequence is Selank (TP-7) and not a related tuftsin analogue sold under a similar name.
- 02Russian-produced material and Chinese-synthesised material are different supply chains; the certificate should tell you which.
- 03Peptide content should be reported alongside purity - a high purity figure on a vial with little actual peptide is not useful.
Search lab reports for this compound →How purity is tested →
Questions
Is Selank approved anywhere?+
It has been used clinically in Russia. It is not approved by the FDA or EMA, and it is sold elsewhere for laboratory research use only.
Why is the research hard to assess?+
Much of the clinical literature is in Russian and outside international trial registries, with often small sample sizes. That makes the evidence volume look stronger than it is to an English-language reader.
How is Selank different from Semax?+
Both are Russian-developed neuropeptides, but they derive from different parent molecules and are studied for different effects. Selank is the anxiolytic; Semax is the nootropic.
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All compounds listed here are supplied for laboratory research use only and are not medicines, supplements, or products for human consumption.